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KMID : 0861420100140020083
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Korean Journal of Nuclear Medicine Technology
2010 Volume.14 No. 2 p.83 ~ p.86
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The Evaluation of Usefulness of Two Times Elution a Day of 99mTc Using 99Mo-99mTc Generator
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Kim Jeong-Ho
Seo Han-Gyeong
Jeong Yeong-Hwan
Kim Yeong-Su
Kim Byung-Cheol
Gwon Yong-Ju
Lee Jeong-Ok
Park Yung-Sun
Kim Dong-Yun
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Abstract
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Purpose: The Molybdenum which is the raw material of 99Mo-99mTc generator (generator) is produced from the nuclear reactor. However, output has dwindled as the two nuclear reactors supplying the bulk of radioactive material-one in Chalk River, Ontario and the other in Petten, the Netherlands-have been closed for repairs or maintenance. This resulted in the enhancement of its price. Therefore we have tried to seek the new method which could run generator to increase activity of 99mTc in this study.
Materials and Methods: The 99mTc activity obtained from 5 times elution for 5 days from Monday to Friday using two generators was compared with 10 times elution. Appearance test, pH test, LAL test, sterility test, chemical impurity(Al) test, radio chemical purity test, ratio of 99Mo/99mTc activity test have been done to check the stability of 99mTc eluting from generator respectively.
Results: The 99mTc activity obtained from 5 times elution for 5 days was 168.2 GBq (4545 mCi) and 10 times was 230.5 GBq (6230 mCi). All quality control tests were within normal limit.
Conclusion: We got to know that 2 times elution a day obtained more 99mTc activity than one time elution in this study.
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KEYWORD
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99Mo-99mTc Generator, 99mTc
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